NFKB1 and central nervous system cancer: Aberrant activation of NF-κB is observed in many types of human tumors, including gliomas, and is regulated by IJBS kinase (IKK-β), which is involved in cell proliferation, cell migration, and angiogenesis (Goldbrunner et al., 1999; Tektonidis et al., 2011; Yang et al., 2014).