miR-451 also reduces invasion, migration, and EMT in glioma cells by targeting CAB39, and thus, inhibiting the Phosphoinositide 3-kinase/protein kinase B/Snail (PI3K/Akt/Snail) signaling pathway (Nan et al., 2021a) miR-661 directly regulates the target gene RAB3D and inhibit AKT/GSK3β signaling, which in turn inhibits glioma cell migration, invasion and EMT (Jin et al., 2020). This evidence concerns the gene AKT1 and central nervous system cancer.