PTEN and central nervous system cancer: miR-32 promotes the transformation of M2 macrophages through the PI3K/AKT signaling pathway, thereby enhancing glioma proliferation and migration, mainly because inhibition of THP1 cells affects their internal phosphatase and tensin homolog (PTEN) expression, which in turn negatively regulates the PI3K/AKT signaling pathway (Bao and Li, 2019).