AKT1 and glioma: Mutant forms of EGFR associated with glioma exhibit constitutive kinase activity, long-term stimulation of RAS signaling to promote cell cycle progression, and activation of the PI3K/AKT pathway to promote cell proliferation and migration (Rong et al., 2009; Ivliev et al., 2010; Mazzoleni et al., 2010).