CDH1 and central nervous system cancer: Epithelial-to-mesenchymal transition is a well-studied physiological process, based on its typical features of imbalanced expression of epithelial markers (E-cadherin) and mesenchymal markers (N-cadherin and Vimentin) leading to a more aggressive or metastatic phenotype (Yang et al., 2008; Thiery et al., 2009), which is the reason they function as glioma-promoting genes.