Previous studies also found that resveratrol upregulated the level of pCREB and prompted the BDNF expression in the hippocampus in a chronic unpredictable mild stress (CUMS) animal model and prevented CUMS-induced cognitive deficits by regulating the CREB/BDNF expression in the hippocampus [64, 65]. Here, CREB1 is linked to Cognitive impairment.