pCREB, BDNF, and PSD-95 decreased in the hippocampus, while CREB did not change; so, 666-15 contributed to the transmission of pain signals, suppressed the activation of the CREB/BDNF signaling pathway in the hippocampus, and weakened the treatment effect of resveratrol on cognitive disorders. Here, CREB1 is linked to cognitive disorder.