PLP1 and neurodegenerative disease: Given the correlation of high doses of PLP protein in the CNS with the neurodegenerative disease PMD, where myelin abnormalities are observed together with late-onset axonopathy [38, 39] and the importance of PLP protein balance with motor and learning behaviors [40], the next question that arose was whether autophagy plays a role in myelin maintenance in the mature CNS (in addition to the PLP homeostasis).