Compared with WAS group, SGD group showed significant differences in metabolic pathways such as taurine and hypotaurine metabolism (2-Hydroxyethanesulfonate, Taurine), purine metabolism (Deoxyadenosine, Urate, Xanthine), sulfur metabolism (L-Homoserine, Taurine), ABC transporters (Deoxyadenosine, N-Acetyl-D-glucosamine, Taurine) and bile secretion (Fluvastatin, Urate). The gene discussed is ABCG2; the disease is specific granule deficiency.