HMGA1 and digestive system disorder: Fluvastatin is a commonly used cholesterol-lowering agent, which can act by inhibiting 3-hydroxy-3-methyl glutaryl coenzyme A reductase (HMGR), and associated with abdominal pain, anorexia (Li et al., 2016), indigestion (Greten et al., 1994) and other digestive system diseases.