TBK1 and amyotrophic lateral sclerosis: Surprisingly, mutant forms of proteins (such as optineurin OPTN and TBK1) involved in mediating mitophagy are associated with ALS (Wong and Holzbaur, 2014; Moore and Holzbaur, 2016; Harding et al., 2021); however, there are few articles related to iPSC-based ALS modeling that characterized by defects in mitophagy.