Given that the PD-associated LRRK2 mutant interacts with DRP1 to recruit and phosphorylate mitochondrial DRP1 (Wang et al., 2012), it is not surprising that Su and Qi found increased mitochondrial fragmentation in LRRK2 G2019S-derived DA neurons, and used P110 to inhibit the hyperactivation of DRP1 to reduce mitochondrial fragments (Su and Qi, 2013). This evidence concerns the gene LRRK2 and Parkinson disease.