Likewise, SNCA (α-synuclein), PARK2 (parkin), PARK7 (DJ-1), PINK1 and LRRK2 are the mutated genes of parkinsonism, among which mutations in both PARK2 (parkin) and LRRK2 are the most common genetic causes (Healy et al., 2008). Here, PRKN is linked to Parkinson disease.