PRKN and Parkinson disease: Regarding PD, its main mutated genes, PARK2 and PINK1, are involved in mitochondrial functions, and there is no doubt that mitochondrial dysfunction is one of the pathological features of Zanon reported that DA neurons derived from the PARK2 mutation carrier iPS-B125 showed fragmented mitochondria, which was compensated by SLP-2 overexpression (Zanon et al., 2017).