Currently, several monogenic inherited CSVDs have been identified, including cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL), cathepsin A‐related arteriopathy with strokes and leukoencephalopathy (CARASAL), hereditary diffuse leukoencephalopathy with spheroids (HDLS), COL4A1/2‐related disorders, and Fabry disease.25, 26. The gene discussed is CTSA; the disease is Leukoencephalopathy.