Shoamanesh et al. found higher levels of circulating TNFR2 in participants with CMBs (OR 2.2, 95% CI 1.1–4.1) in 1763 stroke‐free Framingham offspring, and a secondary analysis further showed that the association was the most prominent in participants with only deep CMBs. This evidence concerns the gene TNFRSF1B and Stroke.