A population‐based study of 268 elderly individuals showed that single pro‐ (IL‐1β, IL‐6, IL‐8, IL‐12, and TNF‐α) and anti‐inflammatory (sIL‐4R anf IL‐10) cytokines were not associated with subcortical WMH, atrophy, or lacunar infarctions, after the Bonferroni correction for multiple comparisons. The gene discussed is TNF; the disease is Atrophy.