To examine the role of IL‐6 trans‐signaling in propagating IS secondary to atrial fibrillation (AF), the ratio between pro‐inflammatory binary IL6:sIL6R complex to the inactive ternary IL6:sIL6R:sgp130 complex (B/T ratio) in 4232 60‐year‐old patients was examined.27 The gene discussed is IL6R; the disease is atrial fibrillation.