It has been demonstrated that H2S can promote angiogenesis in hepatocellular carcinoma (HCC), glioma, and oesophageal cancer by activating the nuclear factor‐kappa B (NF‐κB), p38 mitogen‐activated protein kinase (MAPK)/ERK1/2‐COX‐2 and HSP90 pathways, respectively.85, 86, 87. This evidence concerns the gene MAPK3 and hepatocellular carcinoma.