Similarly, knockdown of PIK3R5 in Irf8−/‐ T‐ALL mice significantly reduced the proportion of GFP+ mCherry+ cells in the BM, suggesting that the knockdown of PIK3R5 is efficient in rescuing the phenotype of increased leukemogenesis caused by Irf8 depletion (Figure 3G and Figure S2C, Supporting Information). This evidence concerns the gene IRF8 and acute lymphoblastic leukemia.