High expression of fat mass‐ and obesity‐associated protein (FTO) in T‐ALL inhibits IRF8 expression by binding to m6A sites in 3’ untranslated region (UTR) of IRF8 messenger RNA (mRNA) and erasing m6A methylation modification, thereby promoting IRF8 mRNA degradation. This evidence concerns the gene IRF8 and acute lymphoblastic leukemia.