They include VHL, PBRM1, SETD2, BAP1, PTEN, MTOR and PIK3CA in ccRCC; the MET, PBRM1, SETD2 and BAP1 in pRCC; the TP53 and PTEN in chRCC. The gene discussed is TP53; the disease is nonpapillary renal cell carcinoma.