IHC staining of CD8+ cells and epithelial cell apoptosis (cleaved caspase 3) 1 to 2 weeks after transplantation of gal 4–KD and scramble-control cell lines revealed higher infiltration of CD8+ cells per mm2 tumor (Fig. 4E), but no significant difference in apoptotic epithelial cells (Supplementary Fig. S3G). This evidence concerns the gene CASP3 and neoplasm.