IQGAP1 and cancer: IQGAP1 is a large multi-domain scaffold protein interacting with numerous proteins such as Rho family of GTPases (Cdc42 and Rac1), ERK1/2, actin-cytoskeleton proteins and several transmembrane receptors.44,45 It serves as a hub of multiple signalling pathways mediating diverse cellular processes such as actin-cytoskeleton dynamics, cell adhesion/signalling, vesicle transport and protein trafficking,45,46 and has been extensively studied in cancer development and metastasis.47 However, whether IQGAP1 plays a role in pain signalling is not known.