TGFBR1 and neoplasm: Compared with VilCreER;Apcfl/+;KrasG12D/+;Alk5+/+ animals, VilCreER;Apcfl/+;KrasG12D/+;Alk5CA mice succumbed significantly more rapidly to their tumour burden (Fig. 4a–c), although we found no appreciable differences in the immune cell infiltrates or stroma (Supplementary Fig. 4a).