Indeed, we and others have previously shown that epithelial-specific loss of Tgfbr1/2 or Smad4 accelerates tumourigenesis in the context of Apc and Kras mutations10,12–14, consistent with key tumour-suppressive roles for epithelial TGFβ signalling in CRC. Here, TGFB1 is linked to colorectal carcinoma.