ATP5PO and neoplasm: The presence of ROS might lead to a downregulation of genes linked to mitochondrial energy metabolism20, such as ATP synthases ATP5O and ATP5D, cytochrome oxidases COX8A and COX7 and NADH dehydrogenases NADUFS8 and NADUFB2 or via ROS intercalation into the DNA double helix promoting tumor cell death35.