Notwithstanding, the high level of DRD2 expression was correlated with the worst survival of GBM patients48 and the use of DRD2 antagonists (e.g. haloperidol52 and trifluoperazine22,53) suppressed the growth of GBM cells by inhibiting mitogenic signaling, and impaired gliomasphere formation, followed by reduction of SOX2 levels, which improved the survival of GBM-mouse models treated with radiotherapy53. This evidence concerns the gene DRD2 and glioblastoma.