Notably, in the context of HNSCC, we found APO, C1 (1-(10,11-dimethoxy-6a,7-dihydro-4H-dibenzo[de,g]quinolin-6(5H)-yl)ethanone) and A5 (2,2,2-trifluoro-1-(1-methylene-3,4-dihydroisoquinolin-2(1H)-yl)ethanone) exerting cytotoxic activity through DNA damage and apoptotic induction through caspase-3 pathway activation24. This evidence concerns the gene AOPEP and head and neck squamous cell carcinoma.