DRD5 and glioblastoma: Although DRD1 and DRD5 expression does not appear to be associated with TMZ response in GBM patients, gene expression data retrieved from The Cancer Genome Atlas (TCGA) correlated high DRD1 and DRD5 expression with worse overall survival of GBM patients50, while DRD5 activation inhibited GBM growth by inducing autophagic cell death51.