Different signaling pathways (e.g. platelet‐derived growth factor, transforming growth factor‐β, leukemia inhibitory factor, Wnt, epidermal growth factor and Notch) can drive the formation of neural/glial stem cells during GBM development, contributing to a diverse variety of stem‐like cells with the capacity of self-renewal, proliferation and differentiation43–45. This evidence concerns the gene EGF and glioblastoma.