In vivo experiments also confirmed that LV-ETS1 Exos could mediate the pro-tumorigenic impact of omental macrophages and promote the metastasis and colonization of ovarian cancer cells to the omentum, Next, we utilized cilengitide to further clarify whether macrophage function was regulated by laminins and integrin αvβ5 interactions. This evidence concerns the gene ETS1 and ovarian cancer.