ETS1 can drive ovarian cancer cells to release exosomes with higher laminin levels, thereby accelerating the exosomes-mediated pro-metastatic effects of omental macrophages via the integrin αvβ5/AKT/Sp1 signaling pathway, and cilengitide can inhibit omental metastasis of ovarian cancer driven by tumor-derived exosomes. The gene discussed is SP1; the disease is ovarian cancer.