Previous studies have reported that RN with a short duration of diabetes (2–3 months) are protected from delay of NCVs, while those with a long duration of diabetes (6 months) are partially protected from the loss of perception and SNCV but not PGP 9.5+ nerve fiber loss, according to suppression of NF-κB activation in DRG neurons (47–49). This evidence concerns the gene NFKB1 and diabetes mellitus.