DES and Hepatic fibrosis: CHCHD2 knockout greatly suppressed TAA-induced liver fibrosis, as evidenced by Sirius red staining (Figure 3K) and reduced expression levels of Des, Timp1, transforming growth factor-β (Tgfb), Col1a1 (P = 0.055), and Col3a1 (P = 0.054) (Supplemental Figure 4).