Noteworthily, CHCHD2 overexpression was found to induce OPN (encoded by gene secreted phosphoprotein 1, Spp1) expression in hepatocytes and mouse liver (Figure 6, B and C), whereas CHCHD2 knockdown decreased the OPN levels in NASH mouse liver (Figure 6D). Here, CHCHD2 is linked to metabolic dysfunction-associated steatohepatitis.