Moreover, hepatic CHCHD2 protein was also upregulated in mice with NASH induced by 24-week feeding with a high-fructose, high-palmitate, and high-cholesterol (FPC) diet (Supplemental Figure 1A; supplemental material available online with this article; https://doi.org/10.1172/jci.insight.162402DS1) (15, 17). This evidence concerns the gene CHCHD2 and metabolic dysfunction-associated steatohepatitis.