Previous studies have suggested an antiapoptotic role of CHCHD2; however, we found that CHCHD2 deletion did not increase cell apoptosis in NASH mouse liver, as evidenced by the TUNEL staining and the unchanged level of cleaved caspase-3 (Supplemental Figure 3, B and C). Here, CHCHD2 is linked to metabolic dysfunction-associated steatohepatitis.