Depletion of c-Jun reduced the total number of detected cisplatin-induced a-SE [with FDR < 0.05, |ILD| ≥ 0.1 and TPM ≥ 1 in one condition (NT or CIS)] by approximately 2-fold, from 2045 in siCtl- to 1042 in sic-Jun-treated cells (compare Figure 1D with Supplementary Figure S6D). The gene discussed is JUN; the disease is in situ carcinoma.