CPB1 and cancer: Links with cancer have also been documented: (i) COASY forms a complex with p85alphaPI3K and affects PI3K signaling (39) (ii) it mediates radiation resistance via PI3K signaling in rectal cancer (40) and (iii) its depletion leads to hyper-acetylation of CPB and Aurora Kinase, elongating mitosis and favoring multi-nucleation in different cancer and non-cancerous cells (41).