When either influenza H3 and H7 hemagglutinin or Severe Acute Respiratory Syndrome (SARS)-related Spike (S) proteins, SARS-CoV S and SARS-CoV-2 S, feature data were used as the test set, the related hemagglutinin or S protein feature data were withheld from the training set but were not included within the test set to ensure non redundancy of feature data during out-of-sample performance evaluation. Here, CHMP5 is linked to severe acute respiratory syndrome.