Here, we propose an important central astrocyte–peripheral white adipocyte axis promoting adipose sympathetic outflows and adipocyte functions through POMC neurons and sympathetic PG, and the adipose sympathetic strength and adipocyte function scaling mediated by glial cells described here may be useful in the development of new therapeutic targets in obesity prevention and treatment. Here, POMC is linked to obesity due to melanocortin 4 receptor deficiency.