GH1 and Down syndrome: Fifty-nine patients (17.1%) had comorbidities, such as Down syndrome, hypotonia, reactive airway disease, isolated cleft palate, cardiac problem, diabetes type 1, receiving growth hormone, autism, thalassemia, Familial Mediterranean Fever (FMF), and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS).