Although tau mainly spreads via the brain’s anatomic connectome, the complete characterization of tauopathies should be based on the notion of Molecular Nexopathy5, which states that divergent spatiotemporal patterns of different tauopathies may result from biochemical differences between tau species and the neural cells in the brain that interact with tau as well as the connectome-based mechanism of transsynaptic transmission5. This evidence concerns the gene MAPT and tauopathy.