MAPT and Alzheimer disease: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that exhibits extracellular amyloid-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta$$\end{document}β plaques and intracellular aggregates of hyperphosphorylated tau as its main neuropathological hallmarks.