The stronger association between tau and regional atrophy, hypometabolism, and cognitive decline in AD3,4 makes it imperative to shift the long-standing focus from amyloid-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta$$\end{document}β to tau and to further investigate modulators of tau accumulation and spread. The gene discussed is MAPT; the disease is Mental deterioration.