The pCR rate in the whole Set 1 cohort, or divided by breast cancer subtype (luminal, HER2 or TNBC) according to the value of p-P70S6K (Thr389), CDK4, filamin A, HMG-CoA reductase and p-Vim (Ser56), is shown in Fig. 4B. The gene discussed is HMGCR; the disease is breast cancer.