ΔΨm flickers induced under cellular stress conditions (i.e., in the presence of staurosporine or oligomycin) were previously shown to lead to local mROS flashes in the mitochondrial matrix and transient ROS emissions in the MAMs, where they sensitized the IP3R to release ER Ca2+ and increase [Ca2+]m in a cancer cell line33. The gene discussed is ITPR1; the disease is cancer.