RRAS2 and ovarian cancer: Given the changes in expression of gene signatures associated with oxidative metabolism and glycolysis found in RRAS2Q72L-deficient ovarian cancer cells (see above, Supplementary Fig. 3E), we next used the Seahorse analyzer (Fig. 7A, B) to investigate the status of these two metabolic routes in gene-edited A2780, CAL-51, and COV362 cells as well as in NIH3T3 cells ectopically expressing specific R-RAS2 mutants.