The combination of INCB3619, a potent inhibitor of ADAM10 and ADAM17, with GW-2974, a dual inhibitor of EGFR and HER-2/neu kinases, resulted in a synergistic growth inhibitory effect on MCF-7 and HER-2/neu-transfected MCF-7 human breast cancer cells [6]. This evidence concerns the gene ERBB2 and breast carcinoma.