APOE and dementia: Therefore, using the large-scale data from 245,483 older adults from the UK Biobank (UKB), we identified the clusters of LTCs in patterns of multimorbidity and performed a prospective cohort study to examine (1) the impact of LTC counts and specific multimorbidity patterns on the risk of dementia (including ACD, AD, and VD); as well as (2) the effect modification by sex, age, or APOE4 status.