Previous reports have linked DCX, a causative gene for X-linked lissencephaly that encodes a neural-specific MT-binding protein, to defects in dynein-based functions (Kaplan and Reiner, 2011; Li et al., 2021; Tanaka et al., 2004). The gene discussed is DCX; the disease is lissencephaly type 1 due to doublecortin gene mutation.