For example, METTL3 synergizes with hepatitis B X-interacting protein (HBXIP) to regulate the abundance of m6A modification of hypoxia-inducible factor-1 alpha (HIF-1α), resulting in metabolic reprogramming and malignant progression of hepatocellular carcinoma cells [10]. This evidence concerns the gene HIF1A and hepatocellular carcinoma.