In addition toATBF1 expression levels, mislocalization of ATBF1 from the nucleus to the cytoplasm was proven to be correlated with cell differentiation and histopathologic progression (including cancer metastasis) in head and neck squamous cell carcinoma [11], colon cancer [8], skin cancer [12] and bladder carcinoma [13]. This evidence concerns the gene ZFHX3 and cancer.