ZFHX3 and hepatocellular carcinoma: For example, in HuH-1 and HuH-7 hepatoma cells, both ATBF1-A and ATBF1-B strongly inhibited the enhancer activity of AFP. In HepG2 hepatoma cells, ATBF1-A inhibited the enhancer activity of AFP, while ATBF1-B promoted its activity [43].