When analyzed for key mediators of the pathway, the transcript level of glycoprotein 130 (gp130) (**P < 0.01) and Signal transducer and activator of transcription 3 (Stat3) (***P < 0.001) were declined in the implanted region of PCOS animal as compared to control group; however, no difference was observed in leukemia inhibitory factor (Lif) and leukemia inhibitory factor levels (Lifr) (Fig. 7). This evidence concerns the gene STAT3 and polycystic ovary syndrome.