PFKFB4 and breast neoplasm: Notably, these alternate roles can contribute to tumor progression with another glycolytic enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) shown to phosphorylate SRC-3 resulting in its transcriptional activation which was shown to drive breast tumor growth and metastasis [2].