Follow-up 3 weeks after dismissal demonstrated persistent adrenal insufficiency with low morning cortisol serum concentration [17 nmol/L (normal range 155–552 nmol/L)] and ACTH serum concentration [< 1.1 pmol/L (normal range 2.2–11.0 nmol/L)] 12 hours after last intake of hydrocortisone. Here, POMC is linked to Adrenal insufficiency.