We then investigated whether the STUB1 mutation caused a functional change in the encoded protein, chaperone-associated E3 ubiquitin ligase (CHIP), which is involved in the ubiquitin-mediated proteasomal control of protein homeostasis, and is known to facilitate degradation of misfolded proteins in neurodegenerative diseases [10]. The gene discussed is STUB1; the disease is neurodegenerative disease.