ENO1 and neoplasm: Immunohistochemical staining for Ki-67 showed that the proliferation activity of tumor cells in the well-differentiated area of the ENO1-con group significantly increased in the hypoxic microenvironment, whereas no significant change was observed in the proliferation ability of tumor cells in the well-differentiated area of the ENO1-knockdown groups (Supplementary Figures S6A–S6F and S7A, S7B).