A study on the expression of TLR8 and TLR7 on bladder transitional cell carcinomas (TCCs) between low-grade (LG) and high-grade (HG) and between non-muscle invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC) in 25 patients who underwent transurethral resection showed an increased expression of TLR7 in LG TCC and NMIBC, and a prevalent expression of TLR-8 in HG TCC and MIBC [89]. The gene discussed is TLR7; the disease is bladder transitional cell carcinoma.