A recent study on the therapeutic applications of TLR agonists in acute myeloid leukemia (AML) demonstrated that R848 has direct antileukemic effects and considerably impairs the growth of human AML cells in immunodeficient mice, suggesting that treatment with TLR8 agonists may be a promising new therapeutic strategy for AML [114]. Here, TLR8 is linked to acute myeloid leukemia.