Targeting follicular helper T cells (TFH) through TLR8 signaling can improve HBsAg specific B cell responses in patients with chronic hepatitis B. TLR8 agonism can enhance HBV-specific B cell responses in CHB patients by improving monocyte-mediated TFH function and may play a role in achieving HBV functional cure [172]. Here, TLR8 is linked to chronic hepatitis B virus infection.