A retrospective study on 166 retrospective primary oral squamous cell carcinoma (OSCC) samples by immunohistochemical staining of TLR7 showed that the low expression of TLR7 in tumor and high expression of TLR7 in stroma predict a good clinical outcome for OSCC patients, and stroma fibroblast-like cells might be amenable to immunotherapy by a TLR7 agonist [90]. This evidence concerns the gene TLR7 and oral cavity squamous cell carcinoma.