In terms of the cytokine response, at the acute stage, the immune response was dominated by Th2-promoting and Th2 cytokines, namely, TSLP, IL-13 and IL-4, while after AD-like dermatitis progressed to its chronicity, other cytokine responses, such as Th1- or Th17-related cytokines, IGFL1 and IL-19, were also markedly elevated. Here, IGFL1 is linked to skin disorder.