By combination of target gene prediction, correlation analysis, survival analysis, and expression determination, a total of 11 potential target genes, involving YAP1, ERBB2, MST1R, YWHAZ, PDK1, CTNNB1, SP1, CIP2A, PIK3CA, PLAG1, MTPN, and MTDH, were screened in pancreatic adenocarcinoma. This evidence concerns the gene MTPN and pancreatic adenocarcinoma.