For example, miR-375 inhibited progression of hepatocellular carcinoma by targeting JAK2/STAT3 signalling pathway [18]; miR-375 reduced the stemness of gastric cancer cells through triggering ferroptosis [19]; miR-375 also functioned as a tumour suppressor in tongue squamous cell carcinoma [20]. This evidence concerns the gene STAT3 and hepatocellular carcinoma.