As suggested in Figure 4 a and b, among the 16 target genes, only increased expression of 12 genes (YAP1, ERBB2, MST1R, YWHAZ, PDK1, CTNNB1, SP1, CIP2A, PIK3CA, PLAG1, MTPN, and MTDH) was positively linked to poor OS and RFS in PAAD. The gene discussed is PIK3CA; the disease is pancreatic adenocarcinoma.