By combination of target gene prediction, correlation analysis, survival analysis, and expression determination, a total of 11 potential target genes, involving YAP1, ERBB2, MST1R, YWHAZ, PDK1, CTNNB1, SP1, CIP2A, PIK3CA, PLAG1, MTPN, and MTDH, were screened in pancreatic adenocarcinoma. The gene discussed is YWHAZ; the disease is pancreatic adenocarcinoma.