Further, we observed a significant correlation between the ADAR1 copy number and its elevated mRNA expression levels in either iCCAs or several other types of cancer (Fig. 2b and  c, and Supplementary Fig. 2B and C; the expression fold change [tumor/non-tumor] in TCGA-CHOL-iCCA ranked the 1st). This evidence concerns the gene ADAR and neoplasm.