However, the copy number alteration (CNA) analyses based on the SNP array data from the DISC cohort (n = 15), a previous study (GSE49666 from the Gene Expression Omnibus [GEO] database; n = 10) [30] and the iCCAs in the Cancer Genome Atlas-cholangiocarcinoma cohort (TCGA-CHOL-iCCA; n = 29) revealed that the ADAR1 locus at chromosome 1q22 is subjected to significant genomic gains, with a frequency of 27% ~ 55% in iCCA patients (Fig. 2a). The gene discussed is ADAR; the disease is cholangiocarcinoma.