Further, using an exemplary target gene Kip1 ubiquitination-promoting complex 1 (KPC1), we identified an ADAR1-mediated recoding RNA editing event causing an amino acid substitution from methionine (Met) to valine (Val) at codon 8 of KPC1 (p.M8V), conferring a loss-of-function phenotype that neutralizes the tumor-suppressive ability of the unedited KPC1. The gene discussed is RNF123; the disease is neoplasm.