IHC assays showed that in KPC1-WT tumor tissues, the cells with positive cytoplasmic staining of p105 or p50 (designated as p105/p50, due to the limitation of the antibody that cannot discriminate the endogenous p105 from p50) are decreased, but the cells with positive nuclear staining of p105/p50 are increased compared to the empty control tumors (Fig. 6h). The gene discussed is NFKB1; the disease is neoplasm.