The binding of amyloid precursor protein (APP) to death receptor 6 (DR6) eased the necrosis (necroptosis) pathway, and knocking down either APP or DR6 results in a considerable reduction of tumor cell (TC)-induced necroptosis and TCs transendothelial migration (Strilic et al. 2016). Here, TNFRSF21 is linked to neoplasm.