KRT7 and extramammary Paget disease: For instance, a diffuse expression of p16 is conventionally indicative of HSIL but may be observed in EMPD.10 Conversely, KRT7 has been described to distinguish EMPD from vulvar squamous cell carcinoma, yet pagetoid HSIL may exhibit expression of KRT7 as seen in one of our own cases.4,5,11 Additional markers may therefore be useful in distinguishing pagetoid HSIL from EMPD.