In addition to formal histopathologic analysis, this study utilized ReBaGs6, a novel recombinant anti-Tn monoclonal murine IgM specific to clustered Tn antigen but which unlike VVA does not bind to other terminal α-linked GalNAc residues, such as blood group A glycans, to provide the first detailed immunohistochemical analysis of Tn expression in matched samples of adenocarcinoma, peritumoral transitional margin, and normal mucosa from the same patient [21]. The gene discussed is CD40LG; the disease is adenocarcinoma.