Since ACE2 inactivates angiotensin II and inhibits the RAAS, an important regulator of blood pressure, administration of exogenous enzymatically active ACE2 in doses high enough to inhibit virus could result in hypotension, particularly in individuals in whom maintenance of blood pressure is reliant on RAAS activation, such as those in states of intravascular volume depletion or in chronic states of RAAS activation due to renal artery stenosis, heart failure, and cirrhosis. This evidence concerns the gene ACE2 and heart failure.