In addition, IL10RB-DT expression was negatively correlated with tumor-associated macrophage (TAM) signature in 472 patients with melanoma (rho = −0.3, P < 0.05; Fig. 2D) and CD8/CD68 signature in 568 patients with thyroid cancer (rho = −0.53, P < 0.05), 151 patients with acute myeloid leukemia (rho = −0.28, P < 0.05), and 529 patients with low-grade glioma (rho = −0.29, P < 0.05). This evidence concerns the gene CD8A and central nervous system cancer.