Other models used in our investigation were two ovarian cancer cell lines, IGROV1 and TOV112D, and two gynecological cancer cell lines that feature high hTS levels resulting from cross-resistance to cisplatin (C13*, A2780/CP) as well as the corresponding cisplatin-sensitive lines (2008, A2780) (Cardinale et al., 2011; Figure 6A, Figure 6—figure supplement 3, Supplementary file 6B). The gene discussed is APCDD1; the disease is ovarian cancer.