Selective upregulation of AFG3L2 in Purkinje cells of SCA28 patients, along with an exclusive neuronal biochemical phenotype, suggests that AFG3L2 might have a specific, neuro-protective role within the human cerebellum, aligning with the proposed model of cerebellar degeneration within SCA28 patients [85]. The gene discussed is AFG3L2; the disease is spinocerebellar ataxia type 28.