123 patients out of the 556 patients who underwent PCNL developed SIRS. Based on the analysis, female gender, positive urine culture, hs-CRP/albumin ratio, and neutrophil to lymphocyte ratio were independent predictors of post-PCNL SIRS. The optimal cut-off value of the hs-CRP/albumin ratio was 0.06 The gene discussed is ALB; the disease is systemic inflammatory response syndrome.