For example, Duan et al. found that miR-133a is upregulated by adiponectin, thus inhibiting the pyroptosis pathway of cells, and a series of inflammatory factors such as caspase-1, interleukin-1 β (IL-1 β), IL-18, and osteopontin (OPN) are inhibited, resulting in aortic dissection [9]. The gene discussed is SPP1; the disease is Aortic dissection.