Literature review using the following Medical Subject Heading (MeSH) terms including GLP-1 RA, guideline, safety, cardiovascular disease, chronic kidney diseases, obesity, dyslipidaemia, hypertension, nonalcoholic fatty liver diseases, polycystic ovarian syndrome, and perioperative complications of bariatric surgery has identified 4594 publications related to GLP-1 RAs' safety, guidelines in different countries, and potential preventive roles. This evidence concerns the gene GCG and obesity due to melanocortin 4 receptor deficiency.