Literature review using the following Medical Subject Heading (MeSH) terms including GLP-1 RA, guideline, safety, cardiovascular disease, chronic kidney diseases, obesity, dyslipidaemia, hypertension, nonalcoholic fatty liver diseases, polycystic ovarian syndrome, and perioperative complications of bariatric surgery has identified 4594 publications related to GLP-1 RAs' safety, guidelines in different countries, and potential preventive roles. The gene discussed is GCG; the disease is chronic kidney disease.