VEGFA and breast angiosarcoma: VEGFA participates in various developmental processes, including endothelial cell proliferation, cell migration, and apoptosis.5–7 It may also participate in the pathogenesis of BA because it can function as a proinflammatory cytokine.8 Polymorphisms of this functional gene may affect expression regulation, leading to various incidences and severities of disease.9 Thus, clarifying the effects of alterations within the VEGFA gene may provide markers for diagnosis and treatment to reverse progression of BA.